Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Jian Xie; Timothy Owen; Ke Xia; Ajay Vikram Singh; Emiley Tou; Lingyun Li; Brigitte Arduini; Hongmin Li; Leo Q. Wan; Brian Callahan; Chunyu Wang

doi:10.1074/jbc.M114.623264

Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

Jian Xie
, Timothy Owen
, Ke Xia
, Ajay Vikram Singh
, Emiley Tou
, Lingyun Li
, Brigitte Arduini
, Hongmin Li
, Leo Q. Wan
, Brian Callahan
, Chunyu Wang

Chemistry

Binghamton University

Rensselaer Polytechnic Institute
State University of New York Binghamton University
Wadsworth Center for Laboratories and Research

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

Original language	English
Pages (from-to)	11591-11600
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	290
Issue number	18
DOIs	https://doi.org/10.1074/jbc.M114.623264
State	Published - May 1 2015

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title = "Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation",

abstract = "Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.",

author = "Jian Xie and Timothy Owen and Ke Xia and Singh, \{Ajay Vikram\} and Emiley Tou and Lingyun Li and Brigitte Arduini and Hongmin Li and Wan, \{Leo Q.\} and Brian Callahan and Chunyu Wang",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = may,

day = "1",

doi = "10.1074/jbc.M114.623264",

language = "English",

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T1 - Zinc inhibits hedgehog autoprocessing

T2 - Linking zinc deficiency with hedgehog activation

AU - Xie, Jian

AU - Owen, Timothy

AU - Xia, Ke

AU - Singh, Ajay Vikram

AU - Tou, Emiley

AU - Li, Lingyun

AU - Arduini, Brigitte

AU - Li, Hongmin

AU - Wan, Leo Q.

AU - Callahan, Brian

AU - Wang, Chunyu

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

AB - Background: In many types of cancers zinc deficiency and overproduction of Hedgehog (Hh) ligand co-exist. Results: Zinc binds to the active site of the Hedgehog-intein (Hint) domain and inhibits Hh ligand production both in vitro and in cell culture. Conclusion: Zinc influences the Hh autoprocessing. Significance: This study uncovers a novel mechanistic link between zinc and the Hh signaling pathway.

UR - https://www.scopus.com/pages/publications/84929485486

U2 - 10.1074/jbc.M114.623264

DO - 10.1074/jbc.M114.623264

M3 - Article

C2 - 25787080

SN - 0021-9258

VL - 290

SP - 11591

EP - 11600

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 18

ER -

Zinc inhibits hedgehog autoprocessing: Linking zinc deficiency with hedgehog activation

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